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Monoamine Oxidase Inhibitors: An Old-School Treatment Option for Depression
Brief Overview Just like SSRIs are considered a “class of antidepressants,” MAOIs, or Monoamine Oxidase Inhibitors, are in a class of their own. MAOIs work by blocking the enzyme responsible for the breakdown of certain neurotransmitters, such as norepinephrine and serotonin. There are two forms of this enzyme (MAO-A and MAO-B), and drugs can block one or both of them. MAOIs are shown to increase serotonin, norepinephrine, dopamine, and tyramine. There is not a large sel
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