What is Buprenorphine (Suboxone)? Suboxone Detoxification Program Buprenorphine (Suboxone) is a medication that is used to treat opioid addiction in the privacy of a physician office or outpatient setting. Buprenorphine (Suboxone) can be taken discreetly from home, by prescription, which makes it different from other forms of managing opioid addiction, such as methadone. The pharmacological and safety profile of buprenorphine (Suboxone) makes it an attractive treatment option