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Alternative Applications for Tricyclic Antidepressants
Tricyclic medications were first introduced in 1957 for the treatment of
depression. Imipramine was the first tricyclic medication shown to be efficacious
for the treatment of depression. Not long after, clomipramine, doxepin,
nortriptyline, and others were subsequently introduced to the United States
market. For the next 30 years, tricyclics were first-line pharmacotherapy for
treatment of depression. However, in 1987, Selective Serotonin Reuptake
Inhibitors (SSRIs) we
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